Causes of Venous Thromboembolism

Based on Virchow triad, venous thrombosis occurs due to the slowdown in the flow / static blood, damage to blood vessel walls, and the increased tendency of blood clots (hiperkoagubilitas). If any of these three factors was not found (no), venous thrombosis did not occur.

In Europe, the presence of blood clots in the veins is the cause of more deaths than AIDS, breast cancer, prostate cancer, and accidents combined. In addition, venous thromboembolism caused death of more than 500,000 people in Europe each year.

A Difficult Diagnosis

Clinical diagnosis of venous thromboembolism is rather difficult because the signs and symptoms are not specific for deep venous thrombosis and pulmonary embolism. Estimated clinical use signs, symptoms, and risk factors for mengkatogerikan patients who have a low probability of experiencing venous thromboembolism, moderate or high normal use.

Prevention of Venous Thromboembolism

Guidelines of the American College of Chest Physicians (ACCP) recommend giving anti-coagulants in high-risk group. For more than 70 years, anti-coagulants have been used to prevent and deal with a potentially fatal blood clots. Currently an oral anticoagulant with a mechanism inhibiting factor Xa has been launched. With consumption once a day, Rivaroxaban, the EU commission has allowed the use of Rivaroxaban as therapy of venous thromboembolism in adult patients who underwent hip or knee surgery. Rivaroxaban is being developed currently use for patients who need preventive treatment of blood clotting. With the direct inhibition of factor Xa in the blood clotting process, Rivaroxaban can regulate the amount of thrombin with no deter tromnin work itself.